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Place components on the board before determining connector pin assignments.
Let the circuit board layout dictate the connector pin location and function assignment.
Divide the circuit board into different DC voltage areas (12 V DC area, 5 V DC area, etc.).
Laterally segregate components based on the DC voltage that they use.
Do not allow different DC voltage planes to overlap one another.
Components using multiple DC voltages must straddle the boundary between the different voltage areas.
Keep all connectors on the same edge of the board.
Keep MHz circuits away from connectors. Do not allow MHz circuits to be located between connectors.
Keep all I/O drivers very close to the connector. Avoid letting the I/O lines come too far onto the board.
Provide space for shunt capacitors on all I/O lines.
Locate components to minimize the length of high speed clock lines.
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